At least nine people have been killed and power at Europe’s largest nuclear plant has been lost after Russia launched missiles across Ukraine.
The attacks hit cities from Kharkiv in the north to Odesa in the south and Zhytomyr in the west.
Buildings and infrastructure were hit in Kharkiv and Odesa, with power blackouts in several areas. Attacks on the capital Kyiv are also reported.
Ukraine said Russia fired 81 missiles, in what is the biggest strike in weeks.
The military claimed it successfully shot down 34 cruise missiles and four of the eight Iranian-made Shahed drones fired.
In western Ukraine, at least five people were killed in Lviv after a rocket hit their home, the region’s governor Maksym Kozytskyi said on Telegram.
Russian shelling killed three people in the southern city of Kherson, where a public transport stop was hit, Ukraine’s presidential chief of staff Andriy Yermak said.
While one person has died and two others were injured following drone and missile strikes in the Dnipropetrovsk region, according to governor Serhii Lysak.
Nuclear energy operator Energoatom said a strike at the Zaporizhzhia plant meant the “last link” between the facility and the Ukrainian power system was cut off.
For the sixth time since it was taken over by Russia, the facility is now operating on diesel generators, which have enough supplies to last 10 days.
Russia-installed officials in the Moscow-controlled part of Ukraine’s Zaporizhzhia region said the halt in electricity supplies to the power station from Ukrainian-held territory was “a provocation”.
Ukrainian President Volodymyr Zelensky said it was “a difficult night”, after Russia resumed its “miserable tactics”.
He said the energy system was being restored and all services were working after the “massive” rocket attack struck critical infrastructure and residential buildings.
In Kyiv, emergency services are at the scenes of blasts in western and southern districts of the capital where the mayor, Vitaly Klitschko, said explosions had taken place.
Mr Klitschko said cars were burning in the courtyard of one residential building and he urged people to stay in shelters. Much of the city has been left without electricity, with four in 10 people without power, he added.
A mass missile attack struck an energy facility in the port city of Odesa, triggering power cuts, its governor Maksym Marchenko said. Residential areas were also hit but no casualties were reported, he added.
“About 15” strikes hit Kharkiv city and region, with “critical infrastructure facilities” and a residential building targeted, regional administration chief Oleg Synegubov said.